產(chǎn)品屬性：
產(chǎn)品名稱 | Tuftsin (human) (trifluoroacetate salt) |
規(guī)格 | 10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y10322 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C21H40N8O6·XCF3COOH
分子量: 500.6
溶解度: DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Tuftsin is an endogenous peptide generated by proteolysis of leukokinin that stimulates phagocytosis.1 It binds human polymorphonuclear leukocytes (PMN), human monocytes, and mouse macrophages with Kd values of 130, 125, and 53 nM, respectively.2 Tuftsin (200 nM) increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages. It increases phagocytosis of the bacteria S. aureus and L. monocytogenes, as well as the fungus S. oviformis, by isolated human, mouse, rabbit, dog, or guinea pig phagocytes when used at concentrations ranging from 0.01 to 0.15 μg/ml.3 Tuftsin (0.1, 0.5, and 25 mg/kg) increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma.41.Najjar, V.A., and Nishioka, K."Tuftsin": A natural phagocytosis stimulating peptideNature228(5272)672-673(1970)
2.Gottlieb, P., Stabinsky, Y., Hiller, T., et al.Tuftsin receptorsAnn. N. Y. Acad. Sci.41993-106(1983)
3.Martinez, J., and Winternitz, F.Bactericidal activity of tuftsinMol. Cell Biochem.41123-136(1981)
4.Catane, R., Schlanger, S., Weiss, L., et al.Toxicology and antitumor activity of tuftsinAnn. N. Y. Acad. Sci.419251-260(1983)
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