產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | UMB298 |
規(guī)格 | 10mM*1 mL in DMSO、5 mg、10 mg、25 mg、50 mg、100 mg |
貨號(hào) | EY-01Y12536 |
Cas No.: 2266569-73-5
別名: N/A
化學(xué)名: N/A
分子式: C27H31ClN4O2
分子量: 479.01
溶解度: DMSO : 25 mg/mL (52.19 mM; Need ultrasonic)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1].[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801.
特別提醒公司產(chǎn)品僅供科研使用
