產品屬性：
產品名稱 | USP7-IN-8 |
規(guī)格 | 5 mg |
貨號 | EY-01Y13037 |
Cas No.: 2009273-60-1
別名: N/A
化學名: N/A
分子式: C21H21N3O2
分子量: 347.41
溶解度: DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.
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