產(chǎn)品屬性：
產(chǎn)品名稱 | THZ1-R |
規(guī)格 | 10mM*1mL in DMSO、1mg、5mg、10mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y13128 |
Cas No.: 1621523-07-6
別名: N/A
化學名: N/A
分子式: C31H30ClN7O2
分子量: 568.07
溶解度: DMSO: ≥ 100 mg/mL (176.03 mM); H2O: < 0.1 mg/mL (insoluble)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.
CDK7|146 nM (IC50)
THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1].[1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.
特別提醒公司產(chǎn)品僅供科研使用
