產(chǎn)品屬性：
產(chǎn)品名稱 | TH-257 |
規(guī)格 | 5mg、10mg、50mg、100mg |
貨號 | EY-01Y13176 |
Cas No.: 2244678-29-1
別名: N/A
化學名: N/A
分子式: C24H26N2O3S
分子量: 422.54
溶解度: DMSO: 250 mg/mL (591.66 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1].[1]. Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458.
特別提醒公司產(chǎn)品僅供科研使用
