產(chǎn)品屬性：
產(chǎn)品名稱 | TPN171 |
規(guī)格 | 100mg、250mg、500mg |
貨號 | EY-01Y17240 |
Cas No.: 1229018-87-4
別名: N/A
化學(xué)名: N/A
分子式: C24H35N5O3
分子量: 441.57
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1].
PDE5|0.62 nM (IC50)
[1]. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.
特別提醒公司產(chǎn)品僅供科研使用
